5/8/2025
Last update
5/8/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (100% as Beta-Carotene)(from Blakeslea trispora and Sunflower Oil)
7,500 mcg
833%
Top Medical Research Studies
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
Read More
Most Useful Reviews
9
Asthma condition resolved
3 people found this helpful
After using this product for some time, I found that it effectively addressed my night blindness and surprisingly also sorted out my asthma. I no longer need to rely on my inhaler. I’m truly grateful for these supplements!
Read More
8
Product effectiveness confirmed
2 people found this helpful
This product definitely worked well for me. I haven’t tried any other beta carotene supplements, but I would consider ordering this one again in the future.
Read More
8
Skin condition enhanced
1 people found this helpful
I absolutely love this product! It boosts my health and improves my skin's smoothness remarkably. Completely natural and gluten-free, I noticed enhancements not only in my skin but also in my overall health and even gained some weight, which was significant for me. Baby hair started growing, which I never had before. Overall, I strongly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
8
We analyzed data from five cycles of the National Health and Nutrition Examination Survey (NHANES), focusing on how dietary retinol (a form of vitamin A) intake relates to rheumatoid arthritis (RA).
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Our findings indicated that higher dietary retinol intake, especially in women, was linked to a reduced risk of developing RA. Specifically, women who consumed more than 354.86 mcg of retinol saw the most significant benefits.
This suggests that adjusting our diets to include more vitamin A could offer a protective effect against this autoimmune disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Asthma condition resolved
3 people found this helpful
After using this product for some time, I found that it effectively addressed my night blindness and surprisingly also sorted out my asthma. I no longer need to rely on my inhaler. I’m truly grateful for these supplements!
Read More
8
Product effectiveness confirmed
2 people found this helpful
This product definitely worked well for me. I haven’t tried any other beta carotene supplements, but I would consider ordering this one again in the future.
Read More
8
Skin condition enhanced
1 people found this helpful
I absolutely love this product! It boosts my health and improves my skin's smoothness remarkably. Completely natural and gluten-free, I noticed enhancements not only in my skin but also in my overall health and even gained some weight, which was significant for me. Baby hair started growing, which I never had before. Overall, I strongly recommend it!
Read More
7.5
Improved skin tone
43 people found this helpful
I am ordering this beta carotene for the third time due to my husband's low vitamin A levels. I followed the package instructions, taking one capsule every other day. Once I noticed a yellowing of my skin, I paused. Prior to summer, I resumed taking it and achieved a tan effortlessly, which I could never do before without burning. My husband's eyes, previously sensitive to sunlight, snow, and wind, stopped watering. They did not retest his vitamin A levels after this.
Read More
6
Quick results observed
3 people found this helpful
I ordered these to enhance the health of my skin and hair. Taking just one capsule daily, I noticed significant changes within three weeks as a yellow tint appeared on my palms, indicating I had replenished my vitamin deficiency. I plan to resume taking them in the autumn to maintain these positive effects. I am thoroughly satisfied with the product's quality!
Read More
Frequently Asked Questions
6
Quick results observed
3 people found this helpful
I ordered these to enhance the health of my skin and hair. Taking just one capsule daily, I noticed significant changes within three weeks as a yellow tint appeared on my palms, indicating I had replenished my vitamin deficiency. I plan to resume taking them in the autumn to maintain these positive effects. I am thoroughly satisfied with the product's quality!
7.5
Improved skin tone
43 people found this helpful
I am ordering this beta carotene for the third time due to my husband's low vitamin A levels. I followed the package instructions, taking one capsule every other day. Once I noticed a yellowing of my skin, I paused. Prior to summer, I resumed taking it and achieved a tan effortlessly, which I could never do before without burning. My husband's eyes, previously sensitive to sunlight, snow, and wind, stopped watering. They did not retest his vitamin A levels after this.
6
Skin improvement noted
7 people found this helpful
My son has suffered from atopic dermatitis since high school. After extensive research, I tried supplements including MSM, zinc, and vitamin C, alongside changing shampoos. Although I faced issues with my skin peeling and cracking, I continued searching for solutions. Eventually, after trying high doses of beta-carotene, I was amazed to see my skin heal; no more redness, and the roughness disappeared. Although I had uncertainties about potential liver damage due to the high intake, my skin’s improvement was undeniable and I felt confident to continue.
9
Asthma condition resolved
3 people found this helpful
After using this product for some time, I found that it effectively addressed my night blindness and surprisingly also sorted out my asthma. I no longer need to rely on my inhaler. I’m truly grateful for these supplements!
8
Skin condition enhanced
1 people found this helpful
I absolutely love this product! It boosts my health and improves my skin's smoothness remarkably. Completely natural and gluten-free, I noticed enhancements not only in my skin but also in my overall health and even gained some weight, which was significant for me. Baby hair started growing, which I never had before. Overall, I strongly recommend it!
9
Vitamin A enhances rheumatoid arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
8
We investigated whether a therapeutic vaccine could target harmful Th17 cells in autoimmune diseases using vitamin A ingredients. By using all-trans retinoic acid (ATRA) in liposomal formulations, we found that it specifically inhibited Th17 cells related to a particular autoantigen, sparing unrelated ones.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
This process not only reduced disease severity in a mouse model of multiple sclerosis, but also encouraged Th17 cells to adopt a more regulatory and tolerant role. Overall, our findings suggest that ATRA-containing vaccines might effectively alter the behavior of Th17 cells in autoimmune conditions.
8
We assessed the potential of all-trans retinoic acid (ATRA), a form of vitamin A, as a treatment for primary immune thrombocytopenia (ITP). Analyzing data from five observational studies and four randomized controlled trials involving 760 patients revealed promising results.
The treatment showed a significant overall response rate of nearly 60%, indicating that ATRA can effectively enhance both initial and long-term responses in ITP patients.
Although some side effects were noted, such as dry skin, they were manageable. Overall, ATRA appears to be a valuable addition to current treatment options for this autoimmune disorder.
The treatment showed a significant overall response rate of nearly 60%, indicating that ATRA can effectively enhance both initial and long-term responses in ITP patients.
Although some side effects were noted, such as dry skin, they were manageable. Overall, ATRA appears to be a valuable addition to current treatment options for this autoimmune disorder.
9
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
References
- Cao TT, Ma JL, Zhang Y, Peng JW, Lin H. Efficacy of formic acid in combination with cDMARDs in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2024;28:4366. 10.26355/eurrev_202410_36831
- Ni Y, Cao Y, Qiu Y, Li Y. Association between dietary retinol intake and rheumatoid arthritis based on NHANES database. BMC Public Health. 2024;24:2167. 10.1186/s12889-024-19620-5
- Zhang Y, Shi J, Xie Y, Shao H, Ning Y, et al. Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy. Clin Exp Rheumatol. 2024;42:1387. 10.55563/clinexprheumatol/3pd9rp
- Banaeeyeh S, Afkhami-Goli A, Moosavi Z, Razavi BM, Hosseinzadeh H. Anti-inflammatory, antioxidant and anti-mitophagy effects of trans sodium crocetinate on experimental autoimmune encephalomyelitis in BALB/C57 mice. Metab Brain Dis. 2024;39:783. 10.1007/s11011-024-01349-0
- Asgari F, Nikzamir A, Baghaei K, Salami S, Masotti A, et al. Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients. Inflammation. 2024;47:1706. 10.1007/s10753-024-02004-7
- Wørzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, et al. Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype. J Autoimmun. 2024;144:103174. 10.1016/j.jaut.2024.103174
- Nehzat N, Browne RW, Ghazal D, Tamaño-Blanco M, Jakimovski D, et al. Exploratory 5-year follow-up study of retinol, tocopherols, and carotenoids in multiple sclerosis. Mult Scler Relat Disord. 2024;81:105143. 10.1016/j.msard.2023.105143
- Uozumi T, Serizawa N, Hagino T, Morita T, Mizuno M, et al. Dietary habits in Japanese patients with bullous pemphigoid: low intake of retinol. Eur J Dermatol. 2023;33:394. 10.1684/ejd.2023.4527
- Mohammadi-Kordkhayli M, Sahraian MA, Ghorbani S, Mansouri F, Talebi F, et al. Vitamins A and D Enhance the Expression of Ror-γ-Targeting miRNAs in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2023;60:5853. 10.1007/s12035-023-03427-3
- Yang J, Zhao L, Wang W, Wu Y. All-trans retinoic acid added to treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Ann Hematol. 2023;102:1695. 10.1007/s00277-023-05263-w
- Moura RP, Carvalho ED, Martins C, des Rieux A, Pêgo AP, et al. Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders. J Control Release. 2023;358:43. 10.1016/j.jconrel.2023.04.034
- McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, et al. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Adv Sci (Weinh). 2023;10:e2202720. 10.1002/advs.202202720
- Sun R, Yang M, Lin C, Wu Y, Sun J, et al. A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome. BMC Ophthalmol. 2023;23:72. 10.1186/s12886-023-02805-8
- Abdelhamid L, Alajoleen R, Kingsmore KM, Cabana-Puig X, Lu R, et al. Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity. Immunohorizons. 2023;7:17. 10.4049/immunohorizons.2200015
- Nasl-Khameneh AM, Mirshafiey A, Moghadasi AN, Yekaninejad MS, Parastouei K, et al. The immunomodulatory effects of all-trans retinoic acid and docosahexaenoic acid combination treatment on the expression of IL-2, IL-4, T-bet, and GATA3 genes in PBMCs of multiple sclerosis patients. Neurol Res. 2023;45:510. 10.1080/01616412.2022.2162222
- Deng C, Zhao X, Chen Y, Ai K, Zhang Y, et al. Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis. ACS Nano. 2022;16:18430. 10.1021/acsnano.2c06584
